Retinal lipidosis in albino rats treated with chlorphentermine and with tricyclic antidepressants
Identifieur interne : 003991 ( Main/Exploration ); précédent : 003990; suivant : 003992Retinal lipidosis in albino rats treated with chlorphentermine and with tricyclic antidepressants
Auteurs : Renate Lüllmann-Rauch [Allemagne]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1976-03-01.
English descriptors
- KwdEn :
- Teeft :
- Abnormal, Abnormal cytoplasmic inclusions, Abnormal inclusions, Acta, Acta neuropath, Adrenal glands, Albino, Albino rats, Amphiphilic, Amphiphilic drugs, Antidepressant, Apical, Apical portion, Apical villous processes, Araldite section, Arrowheads point, Arrows point, Cell biol, Chemical composition, Chloroquine, Chlorphentermine, Control albino, Crystalloid, Crystalloid bodies, Crystalloid inclusions, Crystalloid pattern, Crystalloid variety, Cytoplasmic, Direct continuity, Disc saccules, Drug treatment, Enzymatic degradation, Epithelial, Epithelial cells, Epithelium, Fine structure, Foam cell reaction, Functional implications, Further treatment, Ganglion, Ganglion cells, Identical conditions, Inclusion, Lamellated, Liillmann, Lipid, Lipid material, Lipidosis, Molecular basis, Neuroretina, Opaque cytoplasmic bodies, Other cell types, Outer segment fragment, Outer segment membranes, Outer segments, Pars optica, Periodic pentalaminar pattern, Phagocytosed, Phospholipid, Phospholipid pattern, Photoreceptor, Pigment epithelial cell, Pigment epithelial cells, Pigment epithelium, Retinal, Retinal ganglion cells, Retinal lipidosis, Retinal pigment epithelium, Segment fragment, Segment fragments, Segment membranes, Several weeks, Syrian hamsters, Tricyclic, Tricyclic antidepressants, Virchows arch, Visual cell, Wassermann.
Abstract
Summary: Retinal pigment epithelium is known to be engaged in continuous phagocytosis and digestion of old discs of visual cell outer segments, which have a high phospholipid content. The present ultrastructural study was focused mainly on the effects, upon pigment epithelium, of several drugs that are thought to interfere with the enzymatic degradation of phospholipids. Albino rats received high oral doses of chlorphentermine, iprindole, l-chloroamitriptyline, imipramine, or clomipramine. After treatment for several weeks the pigment epithelial cells were doubled in height due to deposition of excessive amounts of abnormal cytoplasmic inclusions which had a crystalloid substructure. Such inclusions which are known from previous studies to be associated with drug-induced phospholipid storage are suggested to contain non-digestible phospholipids, which in pigment epithelium originate mainly from phagocytosed outer segment discs. The alterations were reversible by withdrawal of the drugs. The functional implications of the epithelial alterations remain to be elucidated. Additional examination of the neuroretina revealed numerous abnormal inclusions, mainly of multilamellated structure. Ganglion cells were affected most. The neuroretinal alterations were reminiscent of those described in human cases of inherited lipidoses.
Url:
DOI: 10.1007/BF00688943
Affiliations:
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Retinal lipidosis in albino rats treated with chlorphentermine and with tricyclic antidepressants</title><author><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:74ED03247D99AC9BE254A3A2D41F0949E1186806</idno><date when="1976" year="1976">1976</date><idno type="doi">10.1007/BF00688943</idno><idno type="url">https://api.istex.fr/ark:/67375/1BB-ST15LSZ9-4/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000673</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000673</idno><idno type="wicri:Area/Istex/Curation">000673</idno><idno type="wicri:Area/Istex/Checkpoint">002738</idno><idno type="wicri:explorRef" wicri:stream="Istex" 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type="city">Kiel</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1976-03-01">1976-03-01</date><biblScope unit="volume">35</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="55">55</biblScope><biblScope unit="page" to="67">67</biblScope></imprint><idno type="ISSN">0001-6322</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6322</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Albino rat</term><term>Chlorphentermine</term><term>Neuroretina</term><term>Phospholipid storage</term><term>Pigment epithelium</term><term>Tricyclic antidepressants</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Abnormal</term><term>Abnormal cytoplasmic inclusions</term><term>Abnormal inclusions</term><term>Acta</term><term>Acta neuropath</term><term>Adrenal glands</term><term>Albino</term><term>Albino rats</term><term>Amphiphilic</term><term>Amphiphilic drugs</term><term>Antidepressant</term><term>Apical</term><term>Apical portion</term><term>Apical villous processes</term><term>Araldite section</term><term>Arrowheads point</term><term>Arrows point</term><term>Cell biol</term><term>Chemical composition</term><term>Chloroquine</term><term>Chlorphentermine</term><term>Control albino</term><term>Crystalloid</term><term>Crystalloid bodies</term><term>Crystalloid inclusions</term><term>Crystalloid pattern</term><term>Crystalloid variety</term><term>Cytoplasmic</term><term>Direct continuity</term><term>Disc saccules</term><term>Drug treatment</term><term>Enzymatic degradation</term><term>Epithelial</term><term>Epithelial cells</term><term>Epithelium</term><term>Fine structure</term><term>Foam cell reaction</term><term>Functional implications</term><term>Further treatment</term><term>Ganglion</term><term>Ganglion cells</term><term>Identical conditions</term><term>Inclusion</term><term>Lamellated</term><term>Liillmann</term><term>Lipid</term><term>Lipid material</term><term>Lipidosis</term><term>Molecular basis</term><term>Neuroretina</term><term>Opaque cytoplasmic bodies</term><term>Other cell types</term><term>Outer segment fragment</term><term>Outer segment membranes</term><term>Outer segments</term><term>Pars optica</term><term>Periodic pentalaminar pattern</term><term>Phagocytosed</term><term>Phospholipid</term><term>Phospholipid pattern</term><term>Photoreceptor</term><term>Pigment epithelial cell</term><term>Pigment epithelial cells</term><term>Pigment epithelium</term><term>Retinal</term><term>Retinal ganglion cells</term><term>Retinal lipidosis</term><term>Retinal pigment epithelium</term><term>Segment fragment</term><term>Segment fragments</term><term>Segment membranes</term><term>Several weeks</term><term>Syrian hamsters</term><term>Tricyclic</term><term>Tricyclic antidepressants</term><term>Virchows arch</term><term>Visual cell</term><term>Wassermann</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Retinal pigment epithelium is known to be engaged in continuous phagocytosis and digestion of old discs of visual cell outer segments, which have a high phospholipid content. The present ultrastructural study was focused mainly on the effects, upon pigment epithelium, of several drugs that are thought to interfere with the enzymatic degradation of phospholipids. Albino rats received high oral doses of chlorphentermine, iprindole, l-chloroamitriptyline, imipramine, or clomipramine. After treatment for several weeks the pigment epithelial cells were doubled in height due to deposition of excessive amounts of abnormal cytoplasmic inclusions which had a crystalloid substructure. Such inclusions which are known from previous studies to be associated with drug-induced phospholipid storage are suggested to contain non-digestible phospholipids, which in pigment epithelium originate mainly from phagocytosed outer segment discs. The alterations were reversible by withdrawal of the drugs. The functional implications of the epithelial alterations remain to be elucidated. Additional examination of the neuroretina revealed numerous abnormal inclusions, mainly of multilamellated structure. Ganglion cells were affected most. The neuroretinal alterations were reminiscent of those described in human cases of inherited lipidoses.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Schleswig-Holstein</li></region><settlement><li>Kiel</li></settlement></list><tree><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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